New Phytol.|中科院植物所发现温度调控植物生长发育与免疫反应间动态平衡的机制

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近日,国际期刊New Phytologist杂志在线发表了中国科学院植物研究所胡玉欣研究组题为“ArabidopsisZED1-related kinases mediate the temperature-sensitive intersection of immune response and growth homeostasis”研究论文,研究报道了温度调控植物生长发育与免疫反应间动态平衡的机理。

Figure. High temperature-dependent growth defect in the Arabidopsis zed1-Dmutant.

植物的生长发育与免疫反应都是耗能的过程,二者间存在动态的平衡。高温条件下,植物在促进生长发育的同时,需要抑制自身的基础免疫反应,以保证更多的物质能量满足生长的需要。然而,目前人们对温度调控植物生长发育与免疫反应间动态平衡的分子机制仍知之甚少。

本研究发现拟南芥ZED1(HopZ-ETI-Deficient 1)显性负突变(zed1-D)造成植物高温下免疫反应自激活和生长发育受阻。部分ZRKs(ZED1-related Kinases)家族成员与ZED1受高温诱导表达,在功能上存在冗余性。进一步研究发现,zed1-D的生长发育缺陷及抗病激活表型依赖于其互作蛋白ZAR1(HOPZ-Activated Resistance 1),而抗性蛋白SNC1(Suppressor of NPR1-1 Constitutive 1)则位于ZED1/ZAR1信号下游,其基因表达受ZRKs抑制。zed1-D是目前报道的首个高温敏感的免疫自激活突变体。通过该突变体的研究,揭示了一条温度调控植物发育与抗病反应间动态平衡的全新机制,将加深我们对植物如何调节生长发育以适应极端变化的环境的认识。

胡玉欣研究组博士研究生王志才、崔大勇博士和博士毕业生刘静为论文共同第一作者,胡玉欣研究员为论文通讯作者。


Activation of the immune response in plants antagonizes growth and development in the absence of pathogens, and such an autoimmune phenotype is often suppressed by the elevation of ambient temperature. However, molecular regulation of the ambient temperature-sensitive intersection of immune response and growth is largely elusive.A genetic screen identified an Arabidopsis mutant, zed1-D, by its high temperature-dependent growth retardation. A combination of molecular, cytological and genetic approaches was used to investigate the molecular basis behind the temperature-sensitive growth and immune response inzed1-D.A dominant mutation in HOPZ-ETI-DEFICIENT 1 (ZED1) is responsible for a high temperature-dependent autoimmunity and growth retardation in zed1-D. The autoimmune phenotype in zed1-Dis dependent on the HOPZ-ACTIVATED RESISTANCE 1 (ZAR1). ZED1 and some ZED1-related kinases (ZRKs) are induced by elevated temperature and function cooperatively to suppress the immune response by modulating the transcription of SUPPRESSOR OF NPR1-1 CONSTITUTIVE 1 (SNC1) in the absence of pathogens.Our data reveal a previously unidentified role of ZRKs in the ambient temperature-sensitive immune response in the absence of pathogens, and thus reveals a possible molecular mechanism underlying the temperature-mediated intersection of immune response and growth in plants.


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